The Japan-UK Regulation through Chromatin Conference took place on 22.-23. August 2022 at the Leicester Institute for Structural and Chemical Biology to bring together the research communities in chromatin biology and epigenetics from the UK and Japan. The focus of this BBSRC-funded conference was on understanding the biology and molecular mechanisms in and around chromatin, and how they regulate transcription, DNA repair and genome maintenance. The conference covered a wide range of aspects and technologies, ranging from atomic structures to the biology of genomes.